Diagnostic Value of Fractional Anisotropy in Detecting Hippocampal Sclerosis: A Study on Intractable Mesial Temporal Lobe Epilepsy with Normal MRI

Hiroshima Journal of Medical Sciences Volume 67 Page 191-198 published_at 2018-05
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Title ( eng )
Diagnostic Value of Fractional Anisotropy in Detecting Hippocampal Sclerosis: A Study on Intractable Mesial Temporal Lobe Epilepsy with Normal MRI
Creator
Sukmaningtyas Hermina
Pandelaki Jacub
Astuti Meira Dewi Kusuma
Fauziah Diah
Riwanto Ignatius
Muttaqin Zainal
Source Title
Hiroshima Journal of Medical Sciences
Volume 67
Start Page 191
End Page 198
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Purpose: This study aimed to investigate whether Fractional Anisotropy (FA) is reliable in detecting hippocampal sclerosis on intractable Mesial Temporal Lobe Epilepsy (MTLE) with normal MRI as measured from the degree of of neuronal loss, gliosis and axonal sprouting. Method: Twenty-three MTLE patients underwent surgery and 10 healthy volunteers were involved in this study. The MTLE diagnosis was based on semiology and ictal EEG, while hippocampal sclerosis was diagnosed using standardized MRI, followed by DTI FA. Histopathological analysis of hippocampus was performed with NeuN, GFAP, and NPY staining to detect the neuronal loss, gliosis, and axonal sprouting. Correlation and Diagnostic test was done to asses of diagnostic value FA. Result: Ten MTLE patients showed normal MR, 4 with hippocampal sclerosis and 6 were with FCD. The value of FA was significantly lower compared with healthy subject. The cut-off point of FA in detecting hippocampal sclerosis was 0.17 (AUC=0.89). The sensitiviy, specificity, positive predictive value, and negative predictive value of FA were 81.8%, 72.3%, 64.3%, and 89.56% respectively. There was significantly correlation between FA with the degrees of neuronal loss and gliosis. The concurrence between FA with EEG 7 out of 10 patients. Conclusion: Fractional Anisotropy has a good diagnostic value in detecting hippocampal sclerosis on normal MRI patients. In addition, this technique also shows a moderate association with degrees of neuronal loss and gliosis.
Keywords
intractable MTLE
normal MRI
DTI
fractional anisotropy
hippocampal sclerosis
Mesial
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2018-05
Rights
Copyright (c) 2018 Hiroshima University Medical Press
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312