Inactivation of the Influenza Virus by a Supplemental Fermented Plant Product (Manda Koso)

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Title ( eng )
Inactivation of the Influenza Virus by a Supplemental Fermented Plant Product (Manda Koso)
Creator
Nomura Toshihito
Yoshimoto Reiko
Kawabata Ryoko
Matsubara Toshiki
Narai Seika
Oda Kosuke
Source Title
Hiroshima Journal of Medical Sciences
Volume 66
Issue 4
Start Page 97
End Page 101
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Manda Koso is a commercial fermented plant product (FPP) made from 53 types of fruits and vegetables that are fermented for more than 3 years. We hypothesized that the FPP can prevent infection by influenza virus and human norovirus. Therefore, we investigated the effects of the FPP on influenza virus and feline calicivirus, a surrogate of human norovirus. We found that 10% FPP inactivated the influenza virus but not the feline calicivirus. Inhibition of the influenza virus was highly concentration-dependent: 1% and 0.3% FPP showed reduced inactivation efficacy. The effects of the FPP on the influenza virus-infected cells were investigated by addition of the FPP to the culture medium after virus infection. No suppressive effect of the FPP on influenza replication in MDCK cells was observed. The results showed that the FPP could inactivate influenza virus by affecting the virus particles.
Keywords
anti-viral reagents
cytotoxicity
influenza virus
feline calicivirus
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2017-12
Rights
Copyright (c) 2017 Hiroshima University Medical Press
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312
[DOI] 10.24811/hjms.66.4_97
[DOI] https://doi.org/10.24811/hjms.66.4_97