Induction of non-specific suppression in chicks by specific combination of maternal antibody and related antigen

Journal of Veterinary Medical Science 77 巻 11 号 1363-1369 頁 2015-06-06 発行
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タイトル ( eng )
Induction of non-specific suppression in chicks by specific combination of maternal antibody and related antigen
作成者
Abou Elazab Mohamed Fahmy
収録物名
Journal of Veterinary Medical Science
77
11
開始ページ 1363
終了ページ 1369
抄録
Specific immune suppression in newly hatched chicks induced by specific maternal antibodies has been reported. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP and non-specific immunoglobulin (Ig) Y antibodies were transferred by yolk sac inoculation to newly hatched chicks, and then, they were immunized with an optimum immunogenic dose of DNP-KLH at 1 and 4 weeks of age. Concentrations of anti-DNP antibodies in serum samples of these chicks were measured by using Enzyme-linked immunosorbent assay (ELISA). Proportions of T-cell subsets in peripheral blood of these chicks were also measured by flow cytometric analysis at 5 weeks of age (one week after the second immunization). Suppression of anti-DNP antibody response and down-regulation of CD3+CD4+ cells were observed in the chicks received high dose of maternal anti-DNP antibodies and immunized with DNP-KLH. On the other hand, normal anti-DNP antibody response and normal proportion of CD3+CD4+ cells were observed in the chicks received high dose of non-specific IgY antibodies and immunized with DNP-KLH. Furthermore, when chicks received high dose of maternal anti-DNP antibodies and immunized with DNP-KLH at 1 and 4 weeks of age and then with rabbit serum albumin (RSA) at 5 and 8 weeks of age, their primary anti-RSA response was also significantly suppressed. We indicate here that specific maternal antibodies can affect both B and T cell responses and induce non-specific suppression against different antigens. However, this non-specific suppression does not continue for a long time.
著者キーワード
chick
maternal antibody
non-specific
suppression
T-cell
内容記述
This study was supported by research project for improving food safety and animal health of the Ministry of Agriculture, Forestry and Fisheries of Japan.
NDC分類
畜産業 [ 640 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
The Japanese Society of Veterinary Science
公益社団法人日本獣医学会
発行日 2015-06-06
権利情報
Copyright (c) 2015 The Japanese Society of Veterinary Science
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/3.0/>.
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[DOI] 10.1292/jvms.14-0525
[ISSN] 1347-7439
[ISSN] 0916-7250
[NCID] AA10796138
[URI] https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_14-0525/_article/