Solitary Cranial Langerhans Cell Histiocytosis : Two case reports
Hiroshima Journal of Medical Sciences Volume 64 Issue 4
Page 59-63
published_at 2015-12
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| File | |
| Title ( eng ) |
Solitary Cranial Langerhans Cell Histiocytosis : Two case reports
|
| Creator |
Karki Prasanna
Hirano Hirofumi
Yamahata Hitoshi
Fujio Shingo
Yonezawa Hajime
Bohara Manoj
Oyoshi Tatsuki
Hanaya Ryosuke
Arita Kazunori
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 64 |
| Issue | 4 |
| Start Page | 59 |
| End Page | 63 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as a unisystem (unifocal or multifocal) or multisystem disease. We describe the clinical and histologic spectrum of LCH of the orbit and skull in our two cases. Both cases had unifocal erosive skull lesions with a history of trauma. Typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunohistochemistry. LCH has an excellent prognosis when treated with surgical resection, steroids and radiotherapy or chemotherapy. One of our patients is disease free at 7 year follow-up and one patient had regression of lesion on follow-up.
|
| Keywords |
Langerhans cell histiocytosis
Skull
Immunostaining
Histology
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 2015-12 |
| Rights |
Hiroshima University Medical Press
|
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
