THE ENHANCING EFFECT OF CYTOCHALASIN A ON CONCANAVALIN A-INDUCED SUPEROXIDE ANION RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES
Hiroshima Journal of Medical Sciences Volume 30 Issue 3
Page 229-236
published_at 1981-09-10
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| File | |
| Title ( eng ) |
THE ENHANCING EFFECT OF CYTOCHALASIN A ON CONCANAVALIN A-INDUCED SUPEROXIDE ANION RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES
|
| Title ( jpn ) |
コンカナバリンA刺激時の多核白血球超酸化物イオン放出に及ぼすサイトカラシンAの増強効果
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| Creator |
Matsuura Ryoji
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| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 30 |
| Issue | 3 |
| Start Page | 229 |
| End Page | 236 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| Abstract |
Superoxide anion release from polymorphonuclear leukocytes stimulated by concanavalin A was markedly enhanced by the simultaneous addition of cytochalasin A at concentrations of 2×10-8 to 4×10-7M. These concentrations of cytochalasin A did not affect the phagocytosis of diisodecyl phthalate emulsion. These concentrations were far lower than those of cytochalasins B, C, D and E that also enhanced concanavalin A-induced superoxide anion release. Superoxide anion release stimulated by concanavalin A and cytochalasin A required the binding of concanavalin A on the cell membrane, and was dependent on the existence of extracellular Ca2+. The enhancement by cytochalasin A was reversible. It is suggested that cytochalasin A acts not only as a sulfhydryl reagent as reported previously, but also has actions resembling the other cytochalasins.
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| Descriptions |
This work has been supported in part by Grants-in-Aid for Scientific Research (Project Nos. 544050, 448227) from the Ministry of Education, Science and Culture of Japan and a Grant-in-Aid from the Japan Medical Research Foundation.
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| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1981-09-10 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6271709
|
