THE ENHANCING EFFECT OF CYTOCHALASIN A ON CONCANAVALIN A-INDUCED SUPEROXIDE ANION RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES
Hiroshima Journal of Medical Sciences 30 巻 3 号
229-236 頁
1981-09-10 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
THE ENHANCING EFFECT OF CYTOCHALASIN A ON CONCANAVALIN A-INDUCED SUPEROXIDE ANION RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES
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| タイトル ( jpn ) |
コンカナバリンA刺激時の多核白血球超酸化物イオン放出に及ぼすサイトカラシンAの増強効果
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| 作成者 |
Matsuura Ryoji
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 30 |
| 号 | 3 |
| 開始ページ | 229 |
| 終了ページ | 236 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| 抄録 |
Superoxide anion release from polymorphonuclear leukocytes stimulated by concanavalin A was markedly enhanced by the simultaneous addition of cytochalasin A at concentrations of 2×10-8 to 4×10-7M. These concentrations of cytochalasin A did not affect the phagocytosis of diisodecyl phthalate emulsion. These concentrations were far lower than those of cytochalasins B, C, D and E that also enhanced concanavalin A-induced superoxide anion release. Superoxide anion release stimulated by concanavalin A and cytochalasin A required the binding of concanavalin A on the cell membrane, and was dependent on the existence of extracellular Ca2+. The enhancement by cytochalasin A was reversible. It is suggested that cytochalasin A acts not only as a sulfhydryl reagent as reported previously, but also has actions resembling the other cytochalasins.
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| 内容記述 |
This work has been supported in part by Grants-in-Aid for Scientific Research (Project Nos. 544050, 448227) from the Ministry of Education, Science and Culture of Japan and a Grant-in-Aid from the Japan Medical Research Foundation.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
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| 発行日 | 1981-09-10 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6271709
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