THE EFFECT OF PANTETHINE, A PRECURSOR OF COENZYME A, ON BILE ACIDS AND LIPIDS IN RATS FED WITH A CHOLESTEROL DIET
Hiroshima Journal of Medical Sciences 30 巻 3 号
215-220 頁
1981-09-10 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
THE EFFECT OF PANTETHINE, A PRECURSOR OF COENZYME A, ON BILE ACIDS AND LIPIDS IN RATS FED WITH A CHOLESTEROL DIET
|
| タイトル ( jpn ) |
コレステロール食投与ラット胆汁酸・胆汁脂質に対するパンテチン，コエンザイムA前駆体の効果
|
| 作成者 |
Kajiyama Goro
Kawamoto Toshio
Fukuhara Choho
Horiuchi Itaru
Nakagawa Masahiro
Miyoshi Akima
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 30 |
| 号 | 3 |
| 開始ページ | 215 |
| 終了ページ | 220 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The effect of pantethine on bile acids and lipids was studied by the washout technique in Wistar female rats fed for four weeks with a 1% cholesterol diet supplemented with 0.5% cholic acid, either containing or not containing 1% pantethine.
Pantethine caused a slight increase in the biliary cholesterol concentration with a significant decrease in the serum cholesterol, β-lipoprotein and triglyceride levels. An increase in the pool size, secretion rate and enterohepatic circulation rate of primary bile acids was at the same time observed in the animals. The production of lithogenic bile was, therefore, inhibited in rats fed with a cholesterol diet treated with pantethine. An analysis of conjugated bile acids revealed a decrease in the glycine/taurine ratio of the whole bile acids as detected by high performance liquid chromatography as a result of pantethine administration. |
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
|
| 発行日 | 1981-09-10 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 7298371
|
