IMMUNOCHEMICAL PROPERTIES AND MOLECULAR FORMS OF UROKINASE
Hiroshima Journal of Medical Sciences 30 巻 4 号
281-286 頁
1981-12-10 発行
アクセス数 : 780 件
ダウンロード数 : 108 件
今月のアクセス数 : 12 件
今月のダウンロード数 : 2 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00038402
| ファイル情報(添付) | |
| タイトル ( eng ) |
IMMUNOCHEMICAL PROPERTIES AND MOLECULAR FORMS OF UROKINASE
|
| タイトル ( jpn ) |
ウロキナーゼ分子異性体の免疫特性
|
| 作成者 |
Toki Naotika
Takasugi Sumiyoshi
Sumi Hiroyuki
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 30 |
| 号 | 4 |
| 開始ページ | 281 |
| 終了ページ | 286 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
1. By the double immunodiffusion technique, highly purified high molecular weight urokinase (HMW-UK; MW 53,000, 124,000 IU/mg protein) and low molecular weight urokinase (LMW-UK; MW 32,000, 230,000 IU/mg protein) revealed the same antigenicity, and their fibrinolytic activities were equally quenched with rabbit antisera against both enzymes.
2. Specific antisera against the functionally-active HMW-UK heavy chain (H-chain; MW 31,000, 201,000 IU/mg protein) and the HMW-UK light chain (L-chain; MW 18,000) were first prepared. By double immunodiffusion anti H-chain serum reacted to all of the active urokinase species (HMW-UK, LMW-UK and H-chain), whereas anti L-chain serum did not react to any of the active enzymes of low molecular form. 3. Anti H-chain serum quenched the fibrinolytic activities of all of the active enzymes in contrast to anti L-chain serum, which had no effect on LMW-UK and H-chain. Anti L-chain serum was found to exert an anti-fibrinolytic effect on HMW-UK. |
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
|
| 発行日 | 1981-12-10 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6086050
|
