High Prevalence of Caecal Dysplasia in Wistar/Furth Substrain Rats
Hiroshima Journal of Medical Sciences 32 巻 3 号
295-299 頁
1983-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
High Prevalence of Caecal Dysplasia in Wistar/Furth Substrain Rats
|
| タイトル ( jpn ) |
Wistar/Furth 亜系ラットに認められた盲腸部異型上皮について
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| 作成者 |
Naito Masashi
Naito Yukiko
Watanabe Hiromitsu
Ito Akihiro
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 32 |
| 号 | 3 |
| 開始ページ | 295 |
| 終了ページ | 299 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Offspring of spontaneous colon tumor prone rats (WF/O) bred in our laboratory developed tumors in a very low incidence (less than 0.2 %), but about half of these rats had dysplastic epithelium with frequent erosion in the caecum. In nine animals (4.4%) submucosal glands of the caecum were observed. These dysplasia accompanied inflammatory cell reactions and regional lymph nodes were enlarged and packed with many plasma cells. Hybrid of WF/O rats and other inbred Long-Evans strain (LE) rats, having no dysplastic lesion of the caecum, had caecal dysplasia in a low incidence (10%). These data suggest that genetic factor(s) play an important role in the occurrence of caecal dysplasia in WF/O rats. These changes may be a precondition to the spontaneous occurrence of tumors in the proximal portion of the ascending colon with the aid of promoting factor(s).
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| 著者キーワード |
Caecal dysplasia
Spontaneous colon tumor
Rats
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
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| 発行日 | 1983-09 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6643108
|
