High Prevalence of Caecal Dysplasia in Wistar/Furth Substrain Rats

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タイトル ( eng )
High Prevalence of Caecal Dysplasia in Wistar/Furth Substrain Rats
タイトル ( jpn )
Wistar/Furth 亜系ラットに認められた盲腸部異型上皮について
作成者
Naito Masashi
Naito Yukiko
Watanabe Hiromitsu
Ito Akihiro
収録物名
Hiroshima Journal of Medical Sciences
32
3
開始ページ 295
終了ページ 299
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
Offspring of spontaneous colon tumor prone rats (WF/O) bred in our laboratory developed tumors in a very low incidence (less than 0.2 %), but about half of these rats had dysplastic epithelium with frequent erosion in the caecum. In nine animals (4.4%) submucosal glands of the caecum were observed. These dysplasia accompanied inflammatory cell reactions and regional lymph nodes were enlarged and packed with many plasma cells. Hybrid of WF/O rats and other inbred Long-Evans strain (LE) rats, having no dysplastic lesion of the caecum, had caecal dysplasia in a low incidence (10%). These data suggest that genetic factor(s) play an important role in the occurrence of caecal dysplasia in WF/O rats. These changes may be a precondition to the spontaneous occurrence of tumors in the proximal portion of the ascending colon with the aid of promoting factor(s).
著者キーワード
Caecal dysplasia
Spontaneous colon tumor
Rats
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University School of Medicine
発行日 1983-09
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6643108