Metabolism of an Antiallergic Agent, Azelastine (4-(p-Chlorobenzyl)-2-[N-Methylperhydroazepinyl-(4)]- 1-(2H)-Phthalazinone Hydrochloride) in Rats and Guinea Pigs
Hiroshima Journal of Medical Sciences Volume 33 Issue 4
Page 669-678
published_at 1984-12
アクセス数 : 920 件
ダウンロード数 : 117 件
今月のアクセス数 : 1 件
今月のダウンロード数 : 2 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00038266
File |
HiroshimaJMedSci_33_669.pdf
584 KB
種類 :
fulltext
|
Title ( eng ) |
Metabolism of an Antiallergic Agent, Azelastine (4-(p-Chlorobenzyl)-2-[N-Methylperhydroazepinyl-(4)]- 1-(2H)-Phthalazinone Hydrochloride) in Rats and Guinea Pigs
|
Title ( jpn ) |
ラットおよびモルモットにおける抗アレルギー剤 azelastine の代謝
|
Creator |
Tatsumi Kiyoshi
Yamada Hideyuki
Yoshimura Hidetoshi
Nishizawa Yukio
Sakai Misao
Mizuo Hitoshi
Yamato Chiyuki
|
Source Title |
Hiroshima Journal of Medical Sciences
|
Volume | 33 |
Issue | 4 |
Start Page | 669 |
End Page | 678 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
Abstract |
The in vivo metabolism of an antiallergic agent, azelastine, (4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride) was examined following oral administration to rats and guinea pigs. As a result, it was found that the drug was metabolized to 4-(p-chlorobenzyl)-2-[N-methyl-7-oxo-perhydroazepinyl-(4)]-1-(2H)-phthalazinone, 6-hydroxy-4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-phthalazinone (6-hydroxyazelastine), 7-hydroxy-4-(p-chlorobenzyl)-2-[N-methyl -perhydroazepinyl-(4)]-1-(2H)-phthalazinone and 4-(p-chlorobenzyl)-2-[perhydroazepinyl-(4)]-1-(2H)-phthalazinone (desmethylazelastine) in these animal bodies. A part of the hydroxy derivatives of the drug was excreted into urine as their glucuronides. In addition, the incubation of azelastine with rat liver microsomes resulted in the formation of 6-hydroxyazelastine and desmethylazelastine in the presence of an NADPH-generating system.
|
Keywords |
Metabolism
Azelastine
|
NDC |
Medical sciences [ 490 ]
|
Language |
eng
|
Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University School of Medicine
|
Date of Issued | 1984-12 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6152559
|