Micronuclei and Chromosome Aberrations Found 1n Bone Marrow Cells and Lymphocytes from Thorotrast Patients and Atomic Bomb Survivors
Hiroshima Journal of Medical Sciences Volume 33 Issue 1
Page 101-111
published_at 1984-03
アクセス数 : 1158 件
ダウンロード数 : 144 件
今月のアクセス数 : 11 件
今月のダウンロード数 : 4 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00038178
File | |
Title ( eng ) |
Micronuclei and Chromosome Aberrations Found 1n Bone Marrow Cells and Lymphocytes from Thorotrast Patients and Atomic Bomb Survivors
|
Title ( jpn ) |
トロトラスト症患者と原爆被爆者の骨髄細胞、リンパ球にみられた血球小核と染色体異常
|
Creator |
Tanaka Kimio
Izumi Takaki
Ohkita Takeshi
Kamada Nanao
|
Source Title |
Hiroshima Journal of Medical Sciences
|
Volume | 33 |
Issue | 1 |
Start Page | 101 |
End Page | 111 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
Abstract |
As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micronucleus and chromosome aberrations in these two exposed groups were significantly higher than that in non-exposed controls. So that these two parameters are useful guide for evaluating the residual effects of radiation, especially on hematopoietic cells. Because of its simple procedures, micronucleus test is also helpful as screening for prediction of chromosome aberrations. The characteristics of lymphocyte chromosome aberrations differed considerably between thorotrast patients and A-bomb survivors; the incidence of unstable type aberrations and intracellular complexity of chromosome aberrations were much higher in the former group. The incidence of micronucleus in erythroblasts and lymphocytes was also higher in thorotrast patients. Such differences are attributable to the differences in the radiation quality (α-ray or γ-ray + neutron) and in the mode of exposure (persistent or single) of these two groups.
|
Keywords |
Micronucleus
Chromosome aberration
Atomic bomb survivors
Thorotrast patients
|
Descriptions |
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Health and Welfare and the Ministry of Education, Science and Culture.
|
NDC |
Medical sciences [ 490 ]
|
Language |
eng
|
Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University School of Medicine
|
Date of Issued | 1984-03 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6480366
|