Function of Trace Metal in Experimental Fulminant Hepatic Failure : Special Reference to Variation in Zinc Content in Liver

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タイトル ( eng )
Function of Trace Metal in Experimental Fulminant Hepatic Failure : Special Reference to Variation in Zinc Content in Liver
タイトル ( jpn )
実験的急性肝不全における重金属動態 : 肝組織亜鉛量の変動を中心に
作成者
Kawanishi Hideki
Nishiki Masayuki
Tsuchiya Taro
Ezaki Haruo
収録物名
Hiroshima Journal of Medical Sciences
33
1
開始ページ 27
終了ページ 33
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
The authors prepared D-galactosamine (Gal) hepatic failure rats and hepatic failure dogs induced by hepatic ischemia and studied the correlation between the progress of hepatic failure and amount of trace metal in liver measured of the rats and dogs.

After Gal was given, the rats rapidly fell into hepatic failure condition. They were sacrificed with the lapse of time and their zinc (Zn) content in liver was measured, which showed a decrease in relation to hepatic injury reaching a minimum of 67. 2 ± 3. 8 μg/g dry weight (that of control group: 149. 1 ± 23. 4, p<0. 05) 48 hr later. The hepatic failure dogs induced by hepatic ischemia also fell into hepatic failure after hepatic ischemia and died 17.5-112 hr (average 57.1 ± 38. 2) later. Positive correlation between the Zn. content in liver immediately after death and the survival time (r= 0. 653, p<0. 01).

As a result, it is suggested that the Zn content in liver can be used as an index to the degree of hepatocyte injury and prognosis of hepatic failure.
著者キーワード
Hepatic failure
Trace metal
Zinc
D-galactosamine
Hepatic ischemia
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University School of Medicine
発行日 1984-03
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6480369