Antitumor Effect of Recombinant Human Lymphotoxin on a Tumor Line of Human Malignant Glioma
Hiroshima Journal of Medical Sciences Volume 38 Issue 3
Page 103-107
published_at 1989-09
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| File | |
| Title ( eng ) |
Antitumor Effect of Recombinant Human Lymphotoxin on a Tumor Line of Human Malignant Glioma
|
| Creator |
Mikami Takashi
Kiya Katsuzo
Mukada Kazutoshi
Kawamoto Keiichi
Hotta Takuhiro
Uozumi Tohru
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 38 |
| Issue | 3 |
| Start Page | 103 |
| End Page | 107 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
We examined the antitumor effect of recombinant human lymphotoxin (rHuLT) on a xenotransplantable human malignant glioma line. Tumor-bearing nude mice were treated with rHuLT for three weeks following four schedules: intratumoral injection of rHuLT 20,000 units once a week, twice a week, intravenous injection once a week and twice a week. The inhibition rate of tumor growth was 98.8%, 99.1 %, 92.1 % and 98.8%, respectively. Histologically, necrotic lesions were observed in the tumors of all treated mice. Thrombo-obstructive changes of tumor vessels were also seen in the tumors of mice after intravenous injection of rHuLT. None of the mice died as a result of this treatment in spite of significant body weight loss. These results indicate that rHuLT has a strong antitumor effect on a xenotransplantable human malignant glioma line.
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| Keywords |
Lymphotoxin
Tumor necrosis factor
Glioma
Xenotransplantable tumor
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1989-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2584052
|
