Lymphocyte Subpopulations in Peripheral Blood and the Spleen from Gastric Cancer Patients
Hiroshima Journal of Medical Sciences Volume 39 Issue 2
Page 23-27
published_at 1990-06
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| File | |
| Title ( eng ) |
Lymphocyte Subpopulations in Peripheral Blood and the Spleen from Gastric Cancer Patients
|
| Creator |
Kuroi Katsumasa
Sato Yukio
Takayama Takahiko
Baba Nobutoshi
Yamaguchi Yoshiyuki
Toge Tetsuya
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 39 |
| Issue | 2 |
| Start Page | 23 |
| End Page | 27 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients were identified by either single or two color analysis with fluorescence activated cell sorter-IV (FACS-IV) using monoclonal antibodies. The absolute and percentages of CD3+ (mature T) cells and CD4 + (helper/inducer T) cells in peripheral blood from the advanced cancer patients were significantly lower than those from normal healthy controls. In peripheral blood, a significant decrease of CD4 + cells was due to the decrease of CD4 + CD45RA + (suppressor inducer T) cells, while CDS+ CD11b+ (suppressor T) cells tended to increase with progress of the disease. CD4+ CD45RA + cells located more predominantly in peripheral blood and spleen than in the splenic vein, while CDS+ CD11b+ cells were more predominant in the splenic vein.
|
| Keywords |
Gastric cancer
Lymphocyte subpopulations
Peripheral blood
Spleen
Monoclonal antibodies
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1990-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2228724
|
