Studies on the Effectiveness of Sairei-to on Puromycin Aminonucleoside Nephrosis in Rats
Hiroshima Journal of Medical Sciences Volume 40 Issue 4
Page 127-135
published_at 1991-12
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| File | |
| Title ( eng ) |
Studies on the Effectiveness of Sairei-to on Puromycin Aminonucleoside Nephrosis in Rats
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| Creator |
Joarder Zahid Hossain
Ogawa Takahiko
Yorioka Noriaki
Yamakido Michio
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| Source Title |
Hiroshima Journal of Medical Sciences
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| Volume | 40 |
| Issue | 4 |
| Start Page | 127 |
| End Page | 135 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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| Abstract |
In order to assess the effectiveness of sairei-to on nephrosis and to elucidate its mechanism of action, we made a puromycin aminonucleoside (PAN) rat model by a single intra-peritoneal injection of PAN at a dose of 100mg/kg body weight (B.W.) and compared it to the normal controls. Sairei-to was administered in various doses (100,200,500mg/kg B.W.) orally for 8 days after the initial injection of PAN. Proteinuria and serum triglyceride levels were significantly reduced in the sairei-to-treated groups which had been pretreated with PAN. Light and electron microscopically sairei-to-treated groups showed a morphological improvement in the kidney over the PAN group. We found 500mg/kg B.W. of sairei-to to be the most effective dose. The superoxide dismutase (SOD)-like activity was significantly elevated in the serum but not changed in the urine of sairei-to-treated groups pretreated with PAN. The normal control fed with 500mg/kg B.W. of sairei-to showed a significant increase in serum SOD-like activity. The urinary prostanoid levels in the PAN group were lower than those in the normal and sairei-to-treated groups. These results support our hypothesis that sairei-to has effects on the elevation of SOD-like activity and on the synthesis of prostanoid in PAN-induced nephrosis, and that these effects are responsible for the mechanism of action of sairei-to.
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| Keywords |
Sairei-to
Puromycin aminonucleoside
Nephrotic syndrome
Superoxide dismutase
Pros tag Jan dins
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| Descriptions |
Parts of this work were presented at the 32nd Annual Meeting of the Japanese Society of Nephrology, November 9-11, 1989, Hamamatsu, Japan; the 20th Western Annual Meeting of the Japanese Society of Nephrology, April 26-27, 1990, Okayama, Japan; the 6th International Congress of Oriental Medicine, October 19-21, 1990, Tokyo, Japan, and the 21st Western Annual Meeting of the Japanese Society of Nephrology, May 31-June 1, 1991, Kobe, Japan.
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1991-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 1797743
|
