Establishment and Characterization of Human Medulloblastoma Xenograft Line
Hiroshima Journal of Medical Sciences Volume 40 Issue 1
Page 41-45
published_at 1991-03
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| File | |
| Title ( eng ) |
Establishment and Characterization of Human Medulloblastoma Xenograft Line
|
| Creator |
Mikami Takashi
Kawamoto Keiichi
Kiya Katsuzo
Mukada Kazutoshi
Hotta Takuhiro
Ogasawara Hidenori
Uozumi Tohru
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 40 |
| Issue | 1 |
| Start Page | 41 |
| End Page | 45 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
A new xenotransplantable tumor line, MED-FU, was derived from a 6-year-old female patient with cerebellar medulloblastoma. This tumor was grown in nude mice as serially transplantable subcutaneous xenografts composed of small round cells with hyperchromatic nuclei and scant cytoplasm. Many rosettes and mitoses were observed. Immunohistochemically, glial fibrillary acidic protein (GFAP), S-100 protein, and neuron specific enolase (NSE) were not detected. The doubling time of the subcutaneous tumors was 6.8 days. Highly concentrated polyamines were detected in the tumor tissue and serum of tumor-bearing mice. This xenotransplanted tumor line, MED-FU, is considered to provide an available experimental model for the study of human medulloblastoma.
|
| Keywords |
Medulloblastoma
Brain tumor
Xenograft
Nude mice
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1991-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 1864766
|
