The Potential for Bidirectional Promoter Activity of the Human PDGF-A Chain Gene
Hiroshima Journal of Medical Sciences Volume 43 Issue 4
Page 119-122
published_at 1994-12
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| File | |
| Title ( eng ) |
The Potential for Bidirectional Promoter Activity of the Human PDGF-A Chain Gene
|
| Creator |
Takimoto Yasuo
Kuramoto Atsushi
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 43 |
| Issue | 4 |
| Start Page | 119 |
| End Page | 122 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Platelet-derived growth factor (PDGF) is a heterodimeric glycoprotein consisting of A and B chains. A functional promoter had been identified in the 5' flanking region of the human PDGF-A chain gene. We found that the PDGF-A chain promoter region possesses the potential for bidirectional activity. This bidirectional promoter activity is influenced by the 5' -untranslated region (5'-UTR) and serum concentration. The 5'-UTR may regulate expression of the PDGF-A chain by transcription in the opposite direction.
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| Keywords |
PDGF-A
Bidirectional promoter
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1994-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
