Restriction Fragment Length Polymorphism of the c-fms Gene in the Human Oral Squamous Cell Carcinomas
Hiroshima Journal of Medical Sciences 43 巻 1 号
23-29 頁
1994-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Restriction Fragment Length Polymorphism of the c-fms Gene in the Human Oral Squamous Cell Carcinomas
|
| 作成者 |
Ohara Masaru
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 43 |
| 号 | 1 |
| 開始ページ | 23 |
| 終了ページ | 29 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
A restriction fragment length polymorphism (RFLP) for the c-fms gene was identified in the human oral squamous cell carcinoma cell lines, Ca9-22, HSC-2 and -3. The RFLP was detected after EcoR I, BamH I and Hind III endonuclease digestion, indicating the presence of two alleles, a and b. The allele a deleted 426bp length of allele b. We determined the sequence of this deletion, that localized in intron 11 with an EcoR I site. The phenotype of Ca9-22 was aa, and the others were bb. Both phenotypes were equally expressed and the transcripts were phosphorylated in these cell lines. The distribution in the analyzed population (66 patients and normal individuals) was 3.1 % homozygotic aa, 13.5% heterozygotic ab and 83.4% homozygotic bb.
|
| 著者キーワード |
c-fms oncogene
Restriction fragment length polymorphism (RFLP)
Oral carcinomas
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| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
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| 発行日 | 1994-03 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|
