Study on Eight Patients with Malignant Tumors after Renal Transplantation

Marubayashi Seiji

Tashiro Hirotaka

Watanabe Hiroshi

Fudaba Yasuhiro

Hayamizu Keisuke

Ohdan Hideki

Okimasa Seiji

Katayama Kohji

Itamoto Toshiyuki

Haruta Naoki

Okajima Masazumi

Kataoka Tsuyoshi

Sugino Keizou

Yahata Hiroshi

Ishikawa Tetsuo

Fukuda Yasuhiko

Dohi Kiyohiko

Asahara Toshimasa

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

The high incidence of cancer after renal transplantation is now a critical concern since the graft survival rate has been improved extensively. We experienced 9 malignancies in 8 patients out of 168 recipients up to December 31, 1999 in our hospital, consisting of a case of gastric plasmacytoma and cases of cancer in the liver (2), thyroid (2), prostate (1), breast (1), sigmoid colon (1) and gall-bladder (1). Two patients were diagnosed as having tumors within 3 months after transplantation, suggesting post-transplant acceleration of growth of the latent tumors. The other patients were diagnosed at an average of 128 months, ranging from 84 to 263 months after transplant. Two patients died of gastro-intestinal bleeding and acute heart failure. Four patients died directly of progressive neoplasm within 3 months after diagnosis. These results suggest that the course of malignancies developing in post-transplant recipients is more aggressive than that expected in non-transplant patients, and it is very important to intensively follow long-term surviving cases to detect the malignant tumors as early as possible.

Malignant Tumor

Renal Transplantation

Medical sciences [ 490 ]

eng

Hiroshima University Medical Press

[ISSN] 0018-2052

[NCID] AA00664312