Intractable Gastrointestinal Bleeding from Angiodysplasia in a Patient of Bernard-Soulier Syndrome : Report of a Case

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Title ( eng )
Intractable Gastrointestinal Bleeding from Angiodysplasia in a Patient of Bernard-Soulier Syndrome : Report of a Case
Creator
Okita Riki
Konishi Kazuo
Osaki Akihiko
Yoshida Kazuhiro
Yamaguchi Yoshiyuki
Toge Tetsuya
Fujimura Kingo
Iwata Takashi
Sawamura Akihiro
Source Title
Hiroshima Journal of Medical Sciences
Volume 54
Issue 4
Start Page 113
End Page 115
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
We herein report a case of gastrointestinal bleeding induced by angiodysplasia of the cecum in a case of Bernard-Soulier syndrome with recurrent breast cancer. In spite of endoscopic hemostatic therapy and interventional embolization, she had repeated massive bleeding from the cecal lesion. In addition, she had chronic hepatitis C and progressive liver tumors metastasized from breast cancer, and she finally died of hepatic failure. There are four case reports in the literature describing Bernard-Soulier syndrome with gastrointestinal bleeding angiodysplasia. The reported cases benefited from hormonal, endoscopical hemostasis and surgical therapy. In our case, because of her terminal metastatic breast cancer, only conservative treatments were administered after the third bleed. Both the endoscopic hemostatic method and interventional embolization showed only a temporary effect. Surgical treatment should be considered if the general condition can tolerate a surgical procedure.
Keywords
Bernard-Soulier syndrome
Gastrointestinal bleeding
Angiodysplasia
Interventional embolization
Breast cancer
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2005-12
Rights
Hiroshima University Medical Press
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312