Cold Saline Injection Attenuates Motor-evoked Potential in the Spinal Cord by Cortical Electrical Stimulation in the Dog
Hiroshima Journal of Medical Sciences 54 巻 3 号
77-82 頁
2005-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Cold Saline Injection Attenuates Motor-evoked Potential in the Spinal Cord by Cortical Electrical Stimulation in the Dog
|
| 作成者 |
Kumagai Hajime
Sugawara Yuji
Isaka Mitsuhiro
Okada Kenji
Orihashi Kazumasa
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| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 54 |
| 号 | 3 |
| 開始ページ | 77 |
| 終了ページ | 82 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Changes in the motor-evoked potential of the spinal cord with transcranial stimulation are monitored for spinal cord function during thoracoabdominal aortic aneurysm surgeries. We examined the effects of changes in motor-evoked potential with cold saline injected into the clamped segment of the aorta, and compared the effects to lidocaine and warm saline injection.
Eighteen dogs were divided into three groups according to the injected agents: Warm saline group (37°C, 20 ml), Cold saline group (4°C, 20 ml), and Lidocaine group (5.0 mg/kg oflidocaine in 20 ml of warm saline), (n=6, each group). Changes in the peak-to-peak MEP amplitude and the indirect wave (I wave) amplitude were measured during aortic cross-clamping. In the peak-to-peak MEP amplitude, the cold saline and lidocaine groups attenuated to 80% of the control value but were not significantly changed. In the I wave amplitude, the cold saline group showed a significant attenuation 1 min after injection (p<0.0001) and the lidocaine group 4 min after injection (p=0.0230), when compared with the warm saline group. Attenuation of the I wave amplitude in the cold saline group was significantly larger than that in the lidocaine group (p=0.0003). Changes in the I wave amplitude appeared within 4 min in both the cold saline and lidocaine groups. Cold saline injection into the clamped segment of the aorta is a diagnostic procedure for determining presiding critical arteries in the segment without experiencing the pharmacological side effects observed with lidocaine injection. |
| 著者キーワード |
Spinal cord ischemia
Cold saline injection
Motor-evoked potential
Thoracoabdominal aortic surgery
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| 内容記述 |
This work was supported by a Grant-in-aid from the Japanese Ministry of Education, Science and Culture.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 2005-09 |
| 権利情報 |
Hiroshima University Medical Press
|
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|
