Six-year Experience of Permanent Prostate Brachytherapy for Clinically Localized Prostate Cancer

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Title ( eng )
Six-year Experience of Permanent Prostate Brachytherapy for Clinically Localized Prostate Cancer
Creator
Kenjo Masahiro
Kobatake Kohei
Iwamoto Hideo
Goriki Akihiro
Oki Mami
Shoji Koichi
Miyamoto Katsutoshi
Masumoto Hiroshi
Kobayashi Kanao
Ohara Shinya
Murakami Yuji
Kaneyasu Yuko
Source Title
Hiroshima Journal of Medical Sciences
Volume 60
Issue 3
Start Page 51
End Page 56
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
This report presents the outcome of prostate permanent brachytherapy (PPB). One hundred and seventy-two patients with clinically localized prostate cancer were treated with permanent brachytherapy using iodine-125 seeds (125-I) at Hiroshima University Hospital from July 2004 to June 2010. This study evaluated the efficacy of PPB in these patients. The median patient age was 69 years (range 53 to 82 years), the median prostate-specific antigen (PSA) value before biopsy was 6.75 ng/ml (range 3.5 to 47.9 ng/ml), and the median prostate volume was 23.1 ml (range 10.1 to 57 ml). The median follow-up was 37 months (range 1 to 72 months). The serum PSA levels decreased continuously after PPB throughout the entire follow-up period in 97% of patients without neoadjuvant hormonal therapy. No relapse occurred during the follow-up period in patients at low risk. Our 6-year experience suggests that PPB is effective for localized prostate cancer. Patients with prostate cancer that does not require combined External beam radiation therapy (EBRT) have the best chance of responding to treatment.
Keywords
Brachytherapy
Localized prostate cancer
Iodine-125 seed
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2011-09
Rights
(c) Hiroshima University Medical Press.
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312