Efficacy of Latanoprost When Stored at Room Temperature
Hiroshima Journal of Medical Sciences 57 巻 2 号
69-72 頁
2008-06 発行
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全文
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タイトル ( eng ) |
Efficacy of Latanoprost When Stored at Room Temperature
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作成者 |
Mochizuki Hideki
Itakura Hideki
Takamatsu Michiya
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収録物名 |
Hiroshima Journal of Medical Sciences
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巻 | 57 |
号 | 2 |
開始ページ | 69 |
終了ページ | 72 |
収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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抄録 |
We compared the ocular hypotensive effect for 24 hours and the tolerability of latanoprost stored at 4 ℃ and 30℃. Seventeen healthy volunteers were included in this crossover trial. Latanoprost 0.005% (Xalatan) was stored at 4℃ or 30℃ for 4 weeks in the dark. The subjects enrolled to the study were randomly assigned to receive either latanoprost stored at 4 ℃ or that stored at 30℃. The eye drop was applied to the right eye of each subject for 3 days. The left eye served as a control without administration. Slit-lamp biomicroscopy and circadian intra ocular pressure (IOP) curve was performed at Day 3, every 3 hours from 6 pm. This procedure was repeated 7 days after changing the drug from 4 ℃ to 30℃ or vice versa, and application to the left eye for 3 days. Eyes treated with latanoprost, stored both at 4 ℃ and 30℃, achieved statistically significantly lower mean IOPs than untreated eyes at all time points, except at 21 hours treated by the drug stored at 30℃. We subtracted the IOP of eyes receiving latanoprost from the IOP of untreated eyes for each time point to evaluate the efficacy of the eye drops (delta IOP). There were no statistically significant differences between the delta IOPs with the drug stored at 4 ℃ and 30℃. During the study, no subject developed a serious adverse event. These results suggest that latanoprost stored at 30℃ for 4 weeks after opening the bottle remains as effective and safe as latanoprost stored under cold conditions.
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著者キーワード |
Latanoprost
Xalatan
Circadian IOP
Sub-optimal storage
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NDC分類 |
医学 [ 490 ]
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言語 |
英語
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資源タイプ | 紀要論文 |
出版者 |
Hiroshima University Medical Press
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発行日 | 2008-06 |
権利情報 |
(c) Hiroshima University Medical Press.
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出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
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