MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer
PLoS ONE 6 巻 10 号
e25438- 頁
2011 発行
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PLoS-One_6_e25438.pdf
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種類 :
全文
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タイトル ( eng ) |
MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer
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作成者 |
Deraz Elsayed Mohamed
Yoshida Maki
Tsunematsu Takaaki
Tani Hirotaka
Siriwardena Samadarani B. S. M.
Kiekhaee Mohammad Reza
Qi Guangying
Iizuka Shinji
Campisi Giuseppina
Muzio Lorenzo Lo
Abiko Yoshimitsu
Kikuchi Akira
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収録物名 |
PLoS ONE
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巻 | 6 |
号 | 10 |
開始ページ | e25438 |
抄録 |
Background: Periostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data sets. In this study, we investigated the roles of MMP-10 in the invasion of HNSCC.
Methods and Findings: We examined the expression of MMP-10 in HNSCC cases by immunohistochemistry. High expression of MMP-10 was frequently observed and was significantly correlated with the invasiveness and metastasis in HNSCC cases. Next, we examined the roles of MMP-10 in the invasion of HNSCC cells in vitro. Ectopic overexpression of MMP-10 promoted the invasion of HNSCC cells, and knockdown of MMP-10 suppressed the invasion of HNSCC cells. Moreover, MMP-10 knockdown suppressed Periostin and Wnt-5b-promoted invasion. Interestingly, MMP-10 overexpression induced the decreased p38 activity and MMP-10 knockdown induced the increased p38 activity. In addition, treatment with a p38 inhibitor SB203580 in HNSCC cells inhibited the invasion. Conclusions: These results suggest that MMP-10 plays an important role in the invasion and metastasis of HNSCC, and that invasion driven by MMP-10 is partially associated with p38 MAPK inhibition. We suggest that MMP-10 can be used as a marker for prediction of metastasis in HNSCC. |
NDC分類 |
医学 [ 490 ]
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
Public Library of Science
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発行日 | 2011 |
権利情報 |
(c) 2011 Deraz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 1932-6203
[DOI] 10.1371/journal.pone.0025438
[DOI] http://dx.doi.org/10.1371/journal.pone.0025438
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