A Miso (Japanese Soybean Paste) Diet Conferred Greater Protection against Hypertension than a Sodium Chloride Diet in Dahl Salt-Sensitive Rats

Hypertension Research Volume 29 Page 731-738 published_at 2006
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Title ( eng )
A Miso (Japanese Soybean Paste) Diet Conferred Greater Protection against Hypertension than a Sodium Chloride Diet in Dahl Salt-Sensitive Rats
Creator
Kashimoto Naoki
Kajimura Junko
Source Title
Hypertension Research
Volume 29
Start Page 731
End Page 738
Abstract
The purpose of this study was to compare the effects of miso and sodium chloride (NaCl) on blood pressure in both sexes of Dahl and SD rats. The systolic and diastolic blood pressures (SBP/DBP) were measured at 2, 4, 8 and 12 weeks of treatment with a miso diet including 2.3% NaCl, a high-sodium diet including 2.3% or 1.9% NaCl, or a normal diet including 0.3% NaCl (MF diet; Oriental Yeast Co., Tokyo, Japan). The rats were autopsied after 12 weeks on a diet. DBP in male Dahl rats was significantly increased by the 2.3% NaCl diet as compared with that in the MF group (p<0.01) or miso group (p<0.05) from 4 weeks of treatment. Thereafter, SBP and DBP in both the high NaCl groups were significantly increased when compared with the MF or miso group. SBP in female Dahl rats on 2.3% NaCl was significantly increased from 8 weeks after treatment. Nephropathy was observed in both sexes of Dahl rats but not SD rats. These results show that blood pressure was not increased by the miso diet.
Keywords
miso
NaCl
hypertension
rat
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
Nature Publishing Group
Date of Issued 2006
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 0916-9636
[DOI] 10.1291/hypres.29.731
[NCID] AA10847079
[DOI] http://dx.doi.org/10.1291/hypres.29.731