Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1
International Journal of Molecular Sciences 11 巻 4 号
1458-1470 頁
2010-04-02 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1
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| 作成者 |
Makihira Seicho
Shuto Takahiro
Okamoto Keishi
Mine Yuichi
Takamoto Yuko
Tsuji Koichiro
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| 収録物名 |
International Journal of Molecular Sciences
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| 巻 | 11 |
| 号 | 4 |
| 開始ページ | 1458 |
| 終了ページ | 1470 |
| 抄録 |
The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
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| 著者キーワード |
antimicrobial peptide
titanium surface
MC3T3-E1 cells
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Molecular Diversity Preservation International-MDPI
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| 発行日 | 2010-04-02 |
| 権利情報 |
Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 1422-0067
[DOI] 10.3390/ijms11041458
[NCID] AA12038549
[DOI] http://dx.doi.org/10.3390/ijms11041458
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