高強度運動における筋疲労の要因 : 無機リン酸, グリコーゲンおよび活性酸素種の影響 <総説>

Possible factors contributing to muscle fatigue during intense exercise : effects of inorganic phosphate, glycogen and reactive oxygen species

和田 正信

坂本 誠

杉山 美奈子

松永 智

体育學研究

Skeletal muscles induced to contract repeatedly respond with a progressive loss in their ability to generate a target force or power. This decline in function, referred to as muscle fatigue, has a complex etiology that can involve various metabolic and ionic factors. Of these, intracellular acidosis due to lactic acid accumulation has been regarded as one of the important causes of muscle fatigue that occurs with intense exercise. Recent surveys, however, have demonstrated little direct effect of acidosis on muscle function at physiological temperatures, and in fact several putative mechanisms by which intracellular changes can attenuate contractile function have been proposed. The most likely mechanisms to explain muscle fatigue include elevated inorganic phosphate concentrations that result from phosphocreatine breakdown, compartmentalized depletion of endogenous muscle glycogen and/or modification by reactive oxygen species that are produced extensively in contracting muscle fibers. This brief review seeks to examine how these three alterations contribute to muscular fatigue processes.

sarcoplasmic reticulum

Ca2+ release channel

oxidative stress

myofibril

excitation-contraction coupling

筋小胞体

Ca2+放出チャンネル

酸化ストレス

筋原線維

興奮収縮連関

スポーツ・体育 [ 780 ]

日本語

日本体育学会

Copyright (c) 2006 日本体育学会

この論文の著作権は(社)日本体育学会に帰属します

[ISSN] 0484-6710

[NCID] AN00409623