Vanadate inhibits endoplasmic reticulum stress responses <Short communication>
European Journal of Pharmacology 594 巻 1-3 号
44-48 頁
2008-10-10 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Vanadate inhibits endoplasmic reticulum stress responses <Short communication>
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| 作成者 |
Kume Ayaka
Okuma Yasunobu
Nomura Yasuyuki
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| 収録物名 |
European Journal of Pharmacology
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| 巻 | 594 |
| 号 | 1-3 |
| 開始ページ | 44 |
| 終了ページ | 48 |
| 抄録 |
The disruption of endoplasmic reticulum function leads to an accumulation of unfolded proteins, which results in endoplasmic reticulum stress. In the present study, we investigated the effect of vanadate on such stress. Endoplasmic reticulum stress increased glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) expressions in glial cell cultures. We found that vanadate inhibited the endoplasmic reticulum stress-induced increase in GRP78 and CHOP expressions at both mRNA and protein levels. Thus, these results suggest that vanadate modulates endoplasmic reticulum stress responses and that novel vanadate-responsive protein(s) might be involved in these processes.
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| 著者キーワード |
endoplasmic reticulum stress
vanadate; glucose-regulated protein 78 (GRP78)
CCAAT/enhancer-binding protein homologous protein (CHOP)
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier Science BV
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| 発行日 | 2008-10-10 |
| 権利情報 |
Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0014-2999
[DOI] 10.1016/j.ejphar.2008.07.034
[NCID] AA00639687
[DOI] http://dx.doi.org/10.1016/j.ejphar.2008.07.034
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