Vanadate inhibits endoplasmic reticulum stress responses <Short communication>
European Journal of Pharmacology Volume 594 Issue 1-3
Page 44-48
published_at 2008-10-10
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| File | |
| Title ( eng ) |
Vanadate inhibits endoplasmic reticulum stress responses <Short communication>
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| Creator |
Kume Ayaka
Okuma Yasunobu
Nomura Yasuyuki
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| Source Title |
European Journal of Pharmacology
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| Volume | 594 |
| Issue | 1-3 |
| Start Page | 44 |
| End Page | 48 |
| Abstract |
The disruption of endoplasmic reticulum function leads to an accumulation of unfolded proteins, which results in endoplasmic reticulum stress. In the present study, we investigated the effect of vanadate on such stress. Endoplasmic reticulum stress increased glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) expressions in glial cell cultures. We found that vanadate inhibited the endoplasmic reticulum stress-induced increase in GRP78 and CHOP expressions at both mRNA and protein levels. Thus, these results suggest that vanadate modulates endoplasmic reticulum stress responses and that novel vanadate-responsive protein(s) might be involved in these processes.
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| Keywords |
endoplasmic reticulum stress
vanadate; glucose-regulated protein 78 (GRP78)
CCAAT/enhancer-binding protein homologous protein (CHOP)
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Elsevier Science BV
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| Date of Issued | 2008-10-10 |
| Rights |
Crown Copyright (c) 2008 Published by Elsevier B.V. All rights reserved.
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0014-2999
[DOI] 10.1016/j.ejphar.2008.07.034
[NCID] AA00639687
[DOI] http://dx.doi.org/10.1016/j.ejphar.2008.07.034
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