μ-Opioid receptor agonist diminishes POMC gene expression and anorexia by central insulin in neonatal chicks
Neuroscience Letters 439 巻 3 号
227-229 頁
2008-07 発行
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種類 :
全文
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タイトル ( eng ) |
μ-Opioid receptor agonist diminishes POMC gene expression and anorexia by central insulin in neonatal chicks
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作成者 |
Shiraishi Jun-ichi
Yanagita Kouichi
Fujita Masanori
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収録物名 |
Neuroscience Letters
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巻 | 439 |
号 | 3 |
開始ページ | 227 |
終了ページ | 229 |
抄録 |
Pro-opiomelanocortin (POMC) neurons in the hypothalamus are direct targets of peripheral satiety signals, such as leptin and insulin in mammals. The stimulation of these signals activates hypothalamic POMC neurons and elevates POMC-derived melanocortin peptides that inhibit food intake in mammals. On the other hand, it has been recognized that β-endorphin, a post-translational processing of POMC, acts in an autoreceptor manner to the μ-opioid receptor (MOR) on POMC neurons, diminishing POMC neuronal activity in mammals. Recently, we found that central insulin functions as an anorexic peptide in chicks. Thus, the present study was done to elucidate whether β-endorphin affects the activation of POMC neurons by insulin in neonatal chicks. Consequently, quantitative real-time PCR analysis shows that intracerebroventricular (ICV) injection of insulin with β-endorphin significantly decreases brain POMC mRNA expression when compared with insulin alone. In addition, co-injection of MOR agonist (β-endorphin or [d-Ala2, N-MePhe4, Gly5-ol]-enkephalin (DAMGO)) significantly attenuates insulin-induced hypophagia in chicks. These data suggest that β-endorphin regulates the activity of the central melanocortin system, and its activation may provide an inhibitory feedback mechanism in the brain of neonatal chicks.
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著者キーワード |
β-Endorphin
food intake
insulin
central nervous system
neonatal chick
melanocortin system
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NDC分類 |
動物学 [ 480 ]
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
Elsevier Ireland Ltd
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発行日 | 2008-07 |
権利情報 |
Copyright (c) 2008 Elsevier Ireland Ltd
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出版タイプ | Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 0304-3940
[NCID] AA00754925
[DOI] 10.1016/j.neulet.2008.05.040
[DOI] http://dx.doi.org/10.1016/j.neulet.2008.05.040
~の異版である
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