CB1 cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substande P release in cultured rat dorsal root ganglion cells
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| File | |
| Title ( eng ) |
CB1 cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substande P release in cultured rat dorsal root ganglion cells
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| Title ( jpn ) |
ラット一次知覚神経におけるCB1カンナビノイド受容体によるバニロイド受容体1活性の制御機構
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| Creator | |
| Abstract |
Cannabinoids have been reported to have analgesic properties in animals of acute nociception or of inflammatory and neuropathic pain models, but the mechanisms by which they exert such alleviative effects are not yet fully understood. We investigated whether the CB1- cannabinoid-receptor agonist HU210 modulates the capsaicin-induced 45Ca2+ influx and substance P like-immunoreactivity (SPLI) release in cultured rat dorsal root ganglion (DRG) cells. HU210 attenuated the capsaicin-induced 45Ca2+ influx and this effect was reversed by the CB1 antagonist AM251. Treatment of DRG cells with 100 nM bradykinin for 3 h potentiated capsaicin-induced SPLI release accompanied with the induction of cyclooxygenase-2 mRNA expression. The potentiation of SPLI release by bradykinin was reversed by HU210 or the protein kinase A (PKA) inhibitor H-89. HU210 also reduced forskolin-induced cyclic AMP production and forskolin-induced potentiation of SPLI release. These results suggest that CBi could inhibit either the capsaicin-induced Ca2+ influx or the potentiation of capsaicin-induced SPLI release by a long-term treatment with bradykinin through involvement of a cyclic-AMP-dependent PKA pathway. In conclusion, CBi-receptor stimulation modulates the activities of transient receptor potential vanilloid receptor 1 in cultured rat DRG cells.
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| Keywords |
CB1 cannabinoid receptor
dorsal root ganglion
protein kinase A
substance P
transient receptor potential vanilloid receptor 1
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| Descriptions |
術後呼吸不全により診断された筋萎縮性側索硬化症の一例. 山田恭子, 井上徹英, 西岡憲吾, 日高昌三, 吉田敬. 麻酔と蘇生 31(3) 209-211, 睡眠時無呼吸を呈したHunter症候群の麻酔経験. 山田恭子, 中川五男, 久保田稔, 仁井内浩, 神谷達. 麻酔 46(7) 955-958, 塩酸ジルチアゼムが内頸静脈血酸素飽和度に及ぼす影響. 山田恭子, 中川五男, 久保田稔, 仁井内浩, 神谷達, 采谷英男, 酒井明彦. 麻酔 47(4) 410-413, Quantitative Measurement of Thromboelastography as a Function of Platelet Count. Kyoko Oshita,Toshiharu Az-ma, Yasuhiro Osawa and Osafumi Yuge. Anesth Analg 1999; 89: 296–9, 群発頭痛の治療法とその効果 : 10症例における検討. 大下恭子, 森脇克行, 福田秀樹, 前原康宏, 河本昌志, 弓削孟文. 麻酔と蘇生 37(1) 9-12, を付す。
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | doctoral thesis |
| Rights |
Copyright(c) by Author
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| Access Rights | open access |
| Source Identifier |
[ISSN] 1347-8613
[NCID] AA11806667
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| Dissertation Number | 甲第3613号 |
| Degree Name | |
| Date of Granted | 2005-03-21 |
| Degree Grantors |
広島大学
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