Bone marrow derived mast cell acquire responsiveness to substance P with Ca2+ signals and release of leukotriene B4 via mitogen-activated protein kinase
Journal of Neuroimmunology 181 巻 1-2 号
1-12 頁
2006-12 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Bone marrow derived mast cell acquire responsiveness to substance P with Ca2+ signals and release of leukotriene B4 via mitogen-activated protein kinase
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| 作成者 |
Okabe Tsutomu
Morita Eishin
Koro Osamu
Yamamoto Shoso
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| 収録物名 |
Journal of Neuroimmunology
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| 巻 | 181 |
| 号 | 1-2 |
| 開始ページ | 1 |
| 終了ページ | 12 |
| 抄録 |
Substance P (SP) selectively activates mast cells that reside in connective tissues. We studied the reactions of bone marrow-derived mast cells (BMMC) of three mouse strains, cultured with or without fibroblasts. BMMC co-cultured with fibroblasts, but not those cultured alone, increased intracellular Ca2+, released LTB4 and histamine in response to SP. PD098059 significantly inhibited the release of LTB4, but not histamine in all strains. SB203580 failed to reduce or slightly impaired the release of LTB4. These results suggest that mast cells undergo maturation under the influence of fibroblasts, acquiring the responsiveness to SP with Ca2+ signals and predominantly ERK-MAP kinase.
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| 著者キーワード |
Ca2+ signal
Leukotriene B4
Mast cell
Mitogen-activated protein kinase
Substance P
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier B.V.
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| 発行日 | 2006-12 |
| 権利情報 |
Copyright (c) 2006 Elsevier B.V.
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0165-5728
[DOI] 10.1016/j.jneuroim.2006.07.011
[NCID] AA1045958X
[PMID] 16952405
[DOI] http://dx.doi.org/10.1016/j.jneuroim.2006.07.011
～の異版である
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