Enhanced biological activity of polymeric osteopontin

FEBS Letters Volume 581 Issue 14 Page 2697-2701 published_at 2007-06-12
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Title ( eng )
Enhanced biological activity of polymeric osteopontin
Creator
Higashikawa Fumiko
Source Title
FEBS Letters
Volume 581
Issue 14
Start Page 2697
End Page 2701
Abstract
Osteopontin is a multifunctional glycoprotein with roles in immunomodulation, inflammatory response, tissue mineralization, and tissue remodeling, which are mediated primarily through integrins. Transglutaminase 2 selectively cross-links proteins by isopeptide bonding. Osteopontin is one of the substrates of this enzyme and undergoes polymerization; however, the biological meaning of this polymerization remains unknown. Using recombinant osteopontin polymerized with purified transglutaminase 2, we examined cell adhesion, spreading, focal contact formation, and migration of SW480 or HUVE cells. All of these cellular behaviors were dramatically enhanced with polymeric osteopontin. These enhancements of cellular functions imply that polymerization might modulate physiological and pathological functions of osteopontin.
Keywords
Osteopontin
Transglutaminase 2
Integrin
Polymerization
NDC
Biology [ 460 ]
Language
eng
Resource Type journal article
Publisher
Elsevier Science B.V.
Date of Issued 2007-06-12
Rights
Copyright (c) 2007 Federation of European Biochemical Societies Published by Elsevier B.V.
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 0014-5793
[DOI] 10.1016/j.febslet.2007.05.018
[NCID] AA00642943
[DOI] http://dx.doi.org/10.1016/j.febslet.2007.05.018