Inhibition of PTEN and activation of Akt by menadione

Biochimica et Biophysica Acta (BBA) - General Subjects 1770 巻 4 号 687-693 頁 2007-04 発行
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タイトル ( eng )
Inhibition of PTEN and activation of Akt by menadione
作成者
Yoshikawa Kyoko
Tsukamoto Mariko
Tamura Namiko
収録物名
Biochimica et Biophysica Acta (BBA) - General Subjects
1770
4
開始ページ 687
終了ページ 693
抄録
Menadione (vitamin K3) has been shown to activate Erk in several cell lines. This effect has been shown to be due to the activation of EGF receptors (EGFR) as a result of inhibition of some protein tyrosine phosphatases. In the present study, we examined the effects of menadione on Akt in Chinese hamster ovary cells. The phosphorylation of Akt by menadione was not inhibited by AG1478, an inhibitor of EGFR. Menadione inhibited the lipid phosphatase activity of PTEN in a cell-free system. In an intact cell system, menadione inhibited the effect of transfected PTEN on Akt. Thus, one mechanism of its action was considered the accelerated activation of Akt through inhibition of PTEN. This was not the sole mechanism responsible for the EGFR-independent activation of Akt, because menadione attenuated the rate of Akt dephosphorylation even in PTEN-null PC3 cells. The decelerated inactivation of Akt, probably through inhibition of some tyrosine phosphatases, was considered another mechanism of its action.
著者キーワード
PTEN
Akt
Naphthoquinone
Menadione (vitamin K3)
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier B.V.
発行日 2007-04
権利情報
Copyright (c) 2007 Elsevier B.V.
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0304-4165
[DOI] 10.1016/j.bbagen.2006.12.009
[PMID] 17276010
[NCID] AA00564679
[DOI] http://dx.doi.org/10.1016/j.bbagen.2006.12.009