Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord
Life Sciences 80 巻 1 号
9-16 頁
2006-12-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord
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| 作成者 |
Abdin Md. Joynal
Kitayama Shigeo
Nakashima Toshikatsu
Dohi Toshihiro
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| 収録物名 |
Life Sciences
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| 巻 | 80 |
| 号 | 1 |
| 開始ページ | 9 |
| 終了ページ | 16 |
| 抄録 |
The activation of cholinergic pathways by nicotine elicits various physiological and pharmacological effects in mammals. For example, the stimulation of nicotinic acetylcholine receptors (nAChRs) leads to an antinociceptive effect. However, it remains to be elucidated which subtypes of nAChR are involved in the antinociceptive effect of nicotine on nerve injury-induced allodynia and the underlying cascades of the nAChR-mediated antiallodynic effect. In this study, we attempted to characterize the actions of nicotine at the spinal level against mechanical allodynia in an animal model of neuropathic pain, tibial nerve transection (TNT) in rats. It was found that the intrathecal injection of nicotine, RJR-2403, a selective 4 2 nAChR agonist, and choline, a selective 7 nAChR agonist, produced an antinociceptive effect on the TNT-induced allodynia. The actions of nicotine were almost completely suppressed by pretreatment with mecamylamine, a non-selective nicotinic antagonist, or dihydro- -erythroidine, a selective 4 2 nAChR antagonist, and partially reversed by pretreatment with methyllycaconitine, a selective 7 nAChR antagonist. Furthermore, pretreatment with strychnine, a glycine receptor antagonist, blocked the antinociception induced by nicotine, RJR-2403, and choline. On the other hand, the GABAA antagonist bicuculline did not reverse the antiallodynic effect of nicotine. Together, these results indicate that the 4 2 and 7 nAChR system, by enhancing the activities of glycinergic neurons at the spinal level, exerts a suppressive effect on the nociceptive transduction in neuropathic pain.
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| 著者キーワード |
nicotine
nicotinic ACh receptor
mechanical allodynia
tibial nerve transection
glycinergic system
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier
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| 発行日 | 2006-12-03 |
| 権利情報 |
Copyright (c) 2006 Elsevier Ltd.
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0024-3205
[DOI] 10.1016/j.lfs.2006.08.011
[NCID] AA00717011
[PMID] 16950410
[DOI] http://dx.doi.org/10.1016/j.lfs.2006.08.011
～の異版である
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