Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression

European Journal of Pharmacology Volume 554 Issue 1 Page 8-11 published_at 2007-01-05

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Title ( eng )	Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression
Creator	Hosoi Toru Hyoda Kanae Okuma Yasunobu Nomura Yasuyuki Ozawa Koichiro
Source Title	European Journal of Pharmacology
Volume	554
Issue	1
Start Page	8
End Page	11
Abstract	Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study, we investigated the effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression. We found that AEBSF completely inhibited PI3K inhibitor-induced CHOP expression at both mRNA and protein levels. It is suggested that AEBSF is an important drug from a pharmacological point of view and the results may have important implications for understanding endoplasmic reticulum stress-related diseases.
Keywords	4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF) phosphatidylinositol 3-kinase (PI3K) CHOP endoplasmic reticulum stress
NDC	Medical sciences [ 490 ]
Language	eng
Resource Type	journal article
Publisher	Elsevier
Date of Issued	2007-01-05
Rights	Copyright (c) 2007 Elsevier Ltd.
Publish Type	Author’s Original
Access Rights	open access
Source Identifier	[ISSN] 0014-2999 [DOI] 10.1016/j.ejphar.2006.09.063 [NCID] AA00639687 [PMID] 17109853 [DOI] http://dx.doi.org/10.1016/j.ejphar.2006.09.063 isVersionOf