Corticospinal tract conduction block results in the prolongation of central motor conduction time in compressive cervical myelopathy

Clinical Neurophysiology 117 巻 3 号 623-627 頁 2006-03 発行
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タイトル ( eng )
Corticospinal tract conduction block results in the prolongation of central motor conduction time in compressive cervical myelopathy
作成者
Fujiwara Yasushi
収録物名
Clinical Neurophysiology
117
3
開始ページ 623
終了ページ 627
抄録
Objective: The objective of this study was to analyze corticospinal function in patients with compressive cervical myelopathy and to elucidate the mechanism underlying its prolonged central motor conduction time (CMCT). Methods: Motor evoked potentials following transcranial magnetic stimulation (TMS) and peripheral conduction time in the ulnar and tibial nerves following electrical stimulation were measured from the abductor digiti minimi (ADM) and abductor hallucis (AH) muscles in 24 patients with compressive cervical myelopathy and used to calculate CMCT. Spinal cord evoked potentials (SCEPs) following transcranial electric stimulation were recorded intraoperatively from the C2-3 to C6-7 intervertebral levels. Correlations between prolonged CMCT and SCEP values were then estimated. Results: The shorter/longer CMCT between the patients' right and left ADM and AH were 8.5 ± 2.9/11.5 ± 3.3 and 16.2 ± 3.1/18.4 ± 3.3 ms, respectively (mean ± SD). The SCEPs amplitude at C6-7, compared to C2-3, was 25.7 ± 21.0 %.0 The attenuation of SCEP amplitude, but not latency, at C6-7 correlated significantly with CMCT prolongation. Conclusions: Our data support the view that CMCT prolongation is primarily due to corticospinal conduction block, rather than conduction delay. Significance: Insight was provided into the mechanism of corticospinal dysfunction in compressive cervical myelopathy.
著者キーワード
motor evoked potentials
central motor conduction time
spinal cord evoked potentials
cervical myelopathy
transcranial magnetic stimulation
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier
発行日 2006-03
権利情報
Copyright (c) 2006 Elsevier Ltd.
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 1388-2457
[DOI] 10.1016/j.clinph.2005.11.010
[NCID] AA11309888
[PMID] 16442342
[DOI] http://dx.doi.org/10.1016/j.clinph.2005.11.010 ~の異版である