Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.
Brain Research 1096 巻 1 号
97-103 頁
2006-06-22 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.
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| 作成者 |
Song Liqiu
Dohi Toshihiro
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| 収録物名 |
Brain Research
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| 巻 | 1096 |
| 号 | 1 |
| 開始ページ | 97 |
| 終了ページ | 103 |
| 抄録 |
Alterations of norepinephrine transporter (NET) function by chroninc inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied. [3H]norepinephrine up take into hippocampus region but not cortex, striatum or amygdalae isolated from mice treated daily for 5 days with desipramine, an inhibitor of NET was significantly decreased. Daily treatment of cocaine increased [3H]norepinephrine uptake into hippocampus. The decrease in norepinephrine uptake induced by chronic desipramine treatment was reversed by co-administration of lidocaine, bupivacaine or tricaine with desipramine. Daily administration of desipramine increased the incidence of appearance of lidocaine-induced convulsions and decreased that of cocaine-induced convulsions. The changes in the convulsive sensitivity to lidocaine and cocaine induced by repeated administration of desipramine was reversed by co-administration of lidocaine with desipramine. These results suggest that down-regulation of hippocampal NET induced by chronic administration of desipramine may be relevant to desipramine-induced sensitization of lidocaine convulsions. Inhibition of Na+ channels by local anesthetics may regulate desipramine-induced down-regulation of NET function. While repeated administration of cocaine caused up-regulation of hipoccampal NET function. Cocaine kindling developed by repeated administration of cocaine may be due to the different mechanisms from those for desipramine-induced sensitization of lidocaine seizures.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier
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| 発行日 | 2006-06-22 |
| 権利情報 |
Copyright (c) 2006 Elsevier Ltd.
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0006-8993
[DOI] 10.1016/j.brainres.2006.04.033
[NCID] AA0057324X
[PMID] 16725121
[DOI] http://dx.doi.org/10.1016/j.brainres.2006.04.033
～の異版である
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