Immunohistochemical evidence for the localization of neurons containing the putative transmitter, L-proline, in rat brain

Brain Research 1073-1074 巻 1 号 311-315 頁 2006-02-16 発行
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タイトル ( eng )
Immunohistochemical evidence for the localization of neurons containing the putative transmitter, L-proline, in rat brain
作成者
Semba Reiji
収録物名
Brain Research
1073-1074
1
開始ページ 311
終了ページ 315
抄録
We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to several groups of neurons in the arcuate nucleus (n) and supraoptic n in the hypothalamus and area postrema. The brainstem had markedly stained fibers in the medial longitudinal fasciculus and localized neuronal cell body labeling in the red n, mesencephalic trigeminal n, lateral reticular n, raphe obscurus n, solitary n, compact ambiguus n, motor trigeminal n, and n of trapezoid body. Our findings are consistent with the hypothesis that L-proline may function as a neurotransmitter or neuromodulator in the brain.
著者キーワード
L-proline
immunohistochemistry
putative neurotransmitter
brainstem
hypothalamus
rats
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier
発行日 2006-02-16
権利情報
Copyright (c) 2006 Elsevier Ltd.
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0006-8993
[DOI] 10.1016/j.brainres.2005.12.064
[NCID] AA0057324X
[PMID] 16458270
[DOI] http://dx.doi.org/10.1016/j.brainres.2005.12.064 ~の異版である