Effects of Weaning by Surrogate Mothers (ACI) on Tumor Development in SD Rats Treatedwith Methylnitrosourea (MNU) and/or N-Methyl-N-nitro-N-nitrosoguanidine (MNNG)
Hiroshima Journal of Medical Sciences 51 巻 3 号
75-79 頁
2002-09-10 発行
アクセス数 : 1506 件
ダウンロード数 : 106 件
今月のアクセス数 : 4 件
今月のダウンロード数 : 0 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00000281
ファイル情報(添付) |
KJ00000010489.pdf
522 KB
種類 :
全文
|
タイトル ( eng ) |
Effects of Weaning by Surrogate Mothers (ACI) on Tumor Development in SD Rats Treatedwith Methylnitrosourea (MNU) and/or N-Methyl-N-nitro-N-nitrosoguanidine (MNNG)
|
作成者 |
Shiraki Katsuhisa
Lu Huimei
Ishimura Yoshimasa
Kashiwabara Shoji
Uesaka Toshihiro
Katoh Osamu
Watanabe Hiromitsu
|
寄与者 | 国立情報学研究所 |
収録物名 |
Hiroshima Journal of Medical Sciences
|
巻 | 51 |
号 | 3 |
開始ページ | 75 |
終了ページ | 79 |
収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
抄録 |
In this experiment, MNU was administered, followed by MNNG, to assess effects ofsurrogate mothering on tumor. One or two day old male SD pups were treated with or without30mg/kg body weight of methylnitrosourea (MNU) and nursed by SD or ACI surrogate mothersfor 5 weeks. When 6-weeks-old they were then treated with 100ppmN-methyl-N-nitro-N-nitrosoguanidine (MNNG) or tap water for 16 weeks. The tumor incidencein the MNNG alone group was significantly lower than with MNU alone or MNU+MNNG (p<0.01).Kidney or nerve tumors mainly developed in the MNU group, gastric tumors in the MNNG group,and the two combined in the MNU+MNNG group. The incidence and mean number of tumors didnot significantly differ between the two weaning groups. However, mean survival time withthe ACI surrogate mothers after treatment with MNU was increased as compared with the SDmother group. Cumulative development of tumors in the ACI surrogate mother group was alsodelayed (p<0.05). Similar results were obtained with MNU+MNNG and MNNG alone. The presentexperiment suggested that tumor induction might be effected by components of the mother'smilk.
|
著者キーワード |
Carcinogen
Rat
Mothers milk
Tumor induction
|
NDC分類 |
医学 [ 490 ]
|
言語 |
英語
|
資源タイプ | 紀要論文 |
出版者 |
Hiroshima University Medical Press
|
発行日 | 2002-09-10 |
出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
日付 |
[作成日] 2006-03-21
|
収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|