Gene therapy for periodontal bioengineering

Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry Page 120-125 published_at 2006-01-08
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Title ( eng )
Gene therapy for periodontal bioengineering
Creator
Cirelli J.A.
Giannobile William V.
Source Title
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
Start Page 120
End Page 125
Abstract
Although significant advancements have been achieved in periodontal therapy over the last decade, predictable regeneration of the tooth-supporting tissues is a challenge in periodontology and oral implantology. Recently, gene therapy, a new therapeutic approach for genetic and acquired diseases, has been applied for tissue bioengineering in multiple clinical situations, including the craniofacial complex, among them defects resulting from periodontal disease. The use of gene therapy vectors has enhanced the bioavailability and targeting of multiple growth and host immune factors to repair alveolar bone defects. Early pre-clinical studies utilizing both ex vivo and in vivo gene transfer strategies demonstrate the feasibility of using gene therapy for periodontal tissue engineering. This review highlights the current progress made in the field of periodontal regenerative medicine via gene targeting approaches.
Keywords
gene therapy
growth factors
tissue engineering
periodontal regeneration
regenerative medicine
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type conference paper
Date of Issued 2006-01-08
Publish Type Version of Record
Access Rights open access
Source Identifier
[URI] http://ir.lib.hiroshima-u.ac.jp/00014842 isPartOf