Relaxing Action of Trp-Nle-Arg-Phe-NH2 on the Anterior Byssus Retractor Muscle of Mytilus
Hiroshima Journal of Medical Sciences Volume 35 Issue 4
Page 381-388
published_at 1986-12
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| File | |
| Title ( eng ) |
Relaxing Action of Trp-Nle-Arg-Phe-NH2 on the Anterior Byssus Retractor Muscle of Mytilus
|
| Creator |
TAKEMOTO Mayumi
SAITOH Hitoshi
MUNEOKA Yojiro
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 35 |
| Issue | 4 |
| Start Page | 381 |
| End Page | 388 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
In the anterior byssus retractor muscle (ABRM) of Mytilus, low concentrations of the molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) relax ACh-induced catch tension, whereas high concentrations cause contraction. In the present studies the actions of a FMRFamide-analog Trp-Nle-Arg-Phe-NH2 (W-Nle-RFamide) on the ABRM were investigated in order to compare them with those of FMRFamide.
The actions of W-Nle-RFamide were qualitatively similar to those of FMRFamide, but catch-relaxing activity of the former peptide was found to be 10-30 times more potent than that of the latter. Cytochemical studies showed that FMRFamide-like immunoreactivity was localized to nerve branches in the ABRM and also to neurons in the pedal ganglion. A peptide which structurally resembles FMRFamide may be involved in the mechanism of the control of relaxation of catch tension in the ABRM of Mytilus. |
| Keywords |
FMRFamide analog
Relaxation
Catch muscle
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1986-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3570846
|
