Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain

Ishida Keishi

Saiki Takashi

Umeda Kanae

Miyara Masatsugu

Sanoh Seigo

Ohta Shigeru

Kotake Yaichiro

Biological and Pharmaceutical Bulletin

Tributyltin (TBT), a common environmental contaminant, is widely used as an antifouling agent in paint. We previously reported that exposure of primary cortical neurons to TBT in vitro decreased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit glutamate receptor 2 (GluR2) expression and subsequently increased neuronal vulnerability to glutamate. Therefore, to identify whether GluR2 expression also decreases after TBT exposure in vivo, we evaluated the changes in GluR2 expression in the mouse brain after prenatal or postnatal exposure to 10 and 25 ppm TBT through pellet diets. Although the mean feed intake and body weight did not decrease in TBT-exposed mice compared with that in control mice, GluR2 expression in the cerebral cortex and hippocampus decreased after TBT exposure during the prenatal period. These results indicate that a decrease in neuronal GluR2 may be involved in TBT-induced neurotoxicity, especially during the fetal period.

tributyltin

glutamate receptor 2

developmental neurotoxicity

Medical sciences [ 490 ]

eng

The Pharmaceutical Society of Japan

© 2017 The Pharmaceutical Society of Japan

[ISSN] 0918-6158

[ISSN] 1347-5215

[NCID] AA10885497

[DOI] 10.1248/bpb.b17-00209

[DOI] https://doi.org/10.1248/bpb.b17-00209