Involvement of Bacterial Antigens in Immunoglobulin A Nephropathy

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タイトル ( eng )
Involvement of Bacterial Antigens in Immunoglobulin A Nephropathy
作成者
Hirabayashi Akira
Yorioka Noriaki
Oda Hiroaki
Sekiguchi Yoshitaka
Kuramoto Atsushi
Okushin Sayuri
Yamakido Michio
収録物名
Hiroshima Journal of Medical Sciences
45
4
開始ページ 113
終了ページ 117
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
To investigate the involvement of bacterial antigens in Immunoglobulin A (IgA) nephropathy, we measured IgA, IgG and IgM antibodies to gram-negative Escherichia coli (E.coli) and Haemophilus influenzae (H.influenzae) by ELISA in 24 patients (11 males and 13 females) with IgA nephropathy and 22 normal controls (11 males and 11 females). The titers of IgA and IgM antibodies for E.coli and H.influenzae were significantly higher in the IgA nephropathy group than in the controls. In addition, IgA and IgM antibody titers for E.coli and H.influenzae showed a significant positive correlation with serum IgA and IgM levels. These findings suggest that subclinical infection by these bacteria stimulates IgA production and that this may be a factor in the development and progression of IgA nephropathy.
著者キーワード
Escherichia coli
Haemophilus influenzae
Immunoglobulin A nephropathy
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 1996-12
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312