Injury and repair of the soleus muscle after electrical stimulation of the sciatic nerve in the rat
Archives of Histology and Cytology Volume 64 Issue 4
Page 393-400
published_at 2001
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Title ( eng ) |
Injury and repair of the soleus muscle after electrical stimulation of the sciatic nerve in the rat
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Creator |
Matsuura Natsue
Ozawa Junya
Kai Satoru
Sakakima Harutoshi
Abiko Sachiko
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Source Title |
Archives of Histology and Cytology
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Volume | 64 |
Issue | 4 |
Start Page | 393 |
End Page | 400 |
Abstract |
To study injury and subsequent changes in skeletal muscles, the rat sciatic nerve was electrically stimulated at 50 Hz and muscle contraction was induced for 30 min. Muscle damage was classified into five types (hypercontraction, hyperstretching, Z band disorders, misalignment of myofilament and regions of scarce myofilaments) by electron microscopy and quantified by ultrastructural assessment. After electrical nerve stimulation, the percentages of the injured areas of the soleus muscle were 18.8 ± 15.8% (mean ± SD) at O h, 9.7 ± 1.0 0x1.3f1c4p-890t 6 h, 22.0 ± 23.6 0x0p+0t 12 h, 13.1 ± 3.2 0x0p+0t 24 h, 4.9 ± 6.0 0x0p+0t 3 days and 0.5 ± 0.4 0x0p+0t 7 days. At 0 h, the vast majority of ultrastructural alterations were sarcomere hypercontraction. At 6 h, hypercontraction was not recognizable and sarcomere hyperstretching and Z band disarrangement constituted the major findings. At 12 h, when the injury reaehed its maximum, myofilament disorganization and hyperstretching were predominant. At 24 h or afterwards, the injury began to decrease and recovered to almost normal conditions by 7 days. There were very few necrotic muscle fibers in all specimens. It is considered that the muscle lesions in the present study were reversible, and recovered through changes in various types of sarcomere alterations. Z band streaming and free ribosomes were frequently found at 12 and 24 h, which may indicate repair processes rather than newly formed lesions.
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | journal article |
Publisher |
International Society of Histology and Cytology
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Date of Issued | 2001 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[NCID] AA1068990X
[ISSN] 0914-9465
[DOI] 10.1679/aohc.64.393
[PMID] 11757908
[DOI] http://dx.doi.org/10.1679/aohc.64.393
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