WMTを経験したラットの遅延調整課題における選択行動の検討

A Study of Choice Behavior in an Adjusting-Delay Task with Working Memory Training Experience in Rats.

SERIKAWA Rena

MATSUMOTO Himeyo

SAKATA Shogo

広島大学大学院人間社会科学研究科紀要. 総合科学研究

Bulletin of the Graduate School of Humanities and Social Sciences, Hiroshima University. Studies in integrated arts and sciences

[PISSN] 2436-2603

[NCID] AA12912965

There are two forms of impulsivity: impulsive behavior and impulsive choice. The adjusting-delay task can measure both forms. Working memory ability is negatively correlated with impulsive choices. Working memory training in human drug-dependent participants further reduced impulsive choices than in the control group (Bickel, Yi, Landes, Hill, & Baxter, 2011). However, in male Long-Evans rats, there was no difference in impulsive choice between the working memory training group and the control group (Renda, Stein, & Madden, 2015). In the present study, we examined the effects of working memory training on impulsive choice in three male Wistar rats. The study consisted of three phases: pre-training, working memory training (WMT), and post-training. An adjusting-delay task was used for pre- and post-training, and the titrating-delay non-matching-to-position task was used for WMT. Despite the improvement in WMT performance, there was no difference in the mean adjusting delay between pre- and posttraining. Focusing on the number of delay time occurrences and the selection rate of larger-later reward lever, it was suggested that after WMT, choice behavior may be based on the length of the delay time. The results of this study may help establish a training method for controlling high impulsivity.

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[ISSN] 2436-2603

[NCID] AA12912965