Indoleamine 2,3-dioxygenase and trophoblast invasion in caesarean scar pregnancy: Implications for the aetiopathogenesis of placenta accreta spectrum

Kudo Yoshiki

Koh Iemasa

Yamazaki Tomomi

Oomori Yuriko

Mukai Yurika

Sugimoto Jun

Journal of Reproductive Immunology

Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive cells. Extravillous cytotrophoblast invasion was present in the myometrium which was not covered by the decidual tissue whereas myometrial invasion of cytotrophoblasts was absent where this tissue lay deep to decidua. These results suggest that indoleamine 2,3-dioxygenase expression in the decidua may normally control trophoblast invasion and absence of its expression where decidua is absent may be involved in the pathogenesis of the over-invaded placenta.

Indoleamine 2,3-dioxygenase (IDO)

Trophoblast invasion

Decidua

Caesarean scar pregnancy

Placenta accreta spectrum (PAS)

eng

Elsevier

© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。

[ISSN] 0165-0378

[DOI] 10.1016/j.jri.2020.103099

[PMID] 32050141

[DOI] https://doi.org/10.1016/j.jri.2020.103099