Lysosomal Enzyme Release from Guinea Pig Polymorphonuclear Leukocytes by Influenza Virus
Hiroshima Journal of Medical Sciences Volume 36 Issue 2
Page 249-255
published_at 1987-06
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| File | |
| Title ( eng ) |
Lysosomal Enzyme Release from Guinea Pig Polymorphonuclear Leukocytes by Influenza Virus
|
| Creator |
KIYOTANI Katsuhiro
TAKEI Naomi
MATSUO Yoshiyasu
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 36 |
| Issue | 2 |
| Start Page | 249 |
| End Page | 255 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Extracellular release and subsequent decrease of intracellular lysosomal enzymes of guinea pig polymorphonuclear leukocytes (PMNLs) by influenza virus were observed. Total enzyme activity was also decreased in all the enzymes assayed. After incubation of the PMNLs with influenza virus at 37°C for 20 min, the degree in decrease of total enzyme activity varied from enzyme to enzyme: 50% in myeloperoxidase (MPO), 20% in acid phosphatase, 10% in N-Ac-β-glucosaminidase and β-glucuronidase and 5% in lysozyme, respectively.
Since MPO assumed to play a critical role in chemiluminescent response of luminol-enhanced system, the dysfunction in oxidative metabolism of PMNLs induced by influenza virus seems to be attributed to intraphagosomal and/or extracellular inactivation of MPO of PMNLs during the process of direct stimulation of respiratory burst. |
| Keywords |
Influenza virus
Lysosomal enzyme release
Myeloperoxidase
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima Journal Medical Press
|
| Date of Issued | 1987-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2820906
|
