Improved Techniques for Orthotopic Liver Transplantation in Pigs: A preliminary study

SAKAGAMI Kenichi

TODA Kohtaro

NAKAI Hajime

HIGAKI Kenji

MORISAKI Futoshi

TAKASU Shinji

MIICHI Noboru

MORISUE Masahiro

SAITO Shinya

MIYAZAKI Masashi

FUCHIMOTO Sadanori

ORITA Kunzo

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Orthotopic liver transplantations were performed on 12 pigs between November, 1986 and February, 1987. Survivals and causes of death were assessed according to the type of surgical procedure employed. Six operations were carried out according to the original procedure of Terblanche et al, whereas for other six animals, the transplantation was conducted by our modified procedure in which cannulation was made into the splenic vein without splenectomy at the veno-venous (v-v) bypass and a diaphragmatic cuff was used for the anastomosis of suprahepatic vena cava. 1/6 animals with original procedure and 5/6 with our modified procedure survived for more than 7 days. The total ischemic time was significantly short in the group subjected to the modified procedure. The major cause of death in the group on which the original procedure was conducted was gastric ulceration, accounting for 67% of the mortality, whereas in the modified procedure group, the mortality rate was reduced significantly to 17%. This operative technique has provided excellent survival rates in our transplanted animals.

Orthotopic liver transplantation

Veno-venous bypass

Porcine liver

Medical sciences [ 490 ]

eng

Hiroshima Journal Medical Press

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 3308789